Exosomes from Microvascular Endothelial Cells under Mechanical Unloading Inhibit Osteogenic Differentiation via miR-92b-3p/ELK4 Axis

Exosomes from Microvascular Endothelial Cells under Mechanical Unloading Inhibit Osteogenic Differentiation via miR-92b-3p/ELK4 Axis

Mechanical unloading-related bone loss adversely harms astronauts’ health. Nevertheless, the specific molecular basis underlying the phenomenon has not been completely elucidated. Although the bone microvasculature contributes significantly to bone homeostasis, the pathophysiological role of microva...

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Bibliographic Details
Main Authors: Xiaoyan Zhang, Lijun Zhang, Liqun Xu, Gaozhi Li, Ke Wang, Tong Xue, Quan Sun, Hao Tang, Xinsheng Cao, Zebing Hu, Shu Zhang, Fei Shi
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Journal of Personalized Medicine
Subjects:
mechanical unloading
exosomes
miR-92b-3p
osteogenic differentiation
Online Access:https://www.mdpi.com/2075-4426/12/12/2030

Internet

https://www.mdpi.com/2075-4426/12/12/2030

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