Tangeretin attenuates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition via the PI3K/Akt pathway

Tangeretin attenuates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition via the PI3K/Akt pathway

Background: Pulmonary fibrosis (PF) is a terminal pathological change in a variety of lung diseases characterized by excessive deposition of extracellular matrix, for which effective treatment is lacking. Tangeretin (Tan), a flavonoid derived from citrus, has been shown to have a wide range of pharm...

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Bibliographic Details
Main Authors: Jiang Li, Qian Wei, Ke Song, Youxin Wang, Yuxin Yang, Miao Li, Jiaying Yu, Guangxu Su, Luyuan Peng, Bendong Fu, Pengfei Yi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary fibrosis
tangeretin
PI3K/Akt signaling pathway
epithelial-mesenchymal transition
bleomycin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1247800/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1247800/full

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