Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson’s Disease

Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson’s Disease

The loss of dopaminergic neurons of the nigrostriatal system underlies the onset of the typical motor symptoms of Parkinson’s disease (PD). Lewy bodies (LB) and Lewy neurites (LN), proteinaceous inclusions mainly composed of insoluble α-synuclein (α-syn) fibrils are key neuropathological hallmarks o...

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Bibliographic Details
Main Authors: Arianna Bellucci, Luigi Bubacco, Francesca Longhena, Edoardo Parrella, Gaia Faustini, Vanessa Porrini, Federica Bono, Cristina Missale, Marina Pizzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
α-synuclein
nuclear factor-κB (NF-κB)
Rel A
c-Rel ko mice
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00068/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2020.00068/full

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