Interleukin-6 and Hypoxia Synergistically Promote EMT-Mediated Invasion in Epithelial Ovarian Cancer via the IL-6/STAT3/HIF-1α Feedback Loop

Interleukin-6 and Hypoxia Synergistically Promote EMT-Mediated Invasion in Epithelial Ovarian Cancer via the IL-6/STAT3/HIF-1α Feedback Loop

Extensive peritoneal spread and capacity for distant metastasis account for the majority of mortality from epithelial ovarian cancer (EOC). Accumulating evidence shows that interleukin-6 (IL-6) promotes tumor invasion and migration in EOC, although the molecular mechanisms remain to be fully elucida...

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Bibliographic Details
Main Authors: Tongshuo Zhang, Jing Yang, Yang Sun, Jiangnan Song, Dandan Gao, Suhui Huang, Aibo Pang, Jianhui Zhang, Junhong Wang, Yue Wang, Yanqiu Li
Format: Article
Language:English
Published: Hindawi Limited 2023-01-01
Series:Analytical Cellular Pathology
Online Access:http://dx.doi.org/10.1155/2023/8334881

Internet

http://dx.doi.org/10.1155/2023/8334881

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