The IL-25/ILC2 axis promotes lung cancer with a concomitant accumulation of immune-suppressive cells in tumors in humans and mice

The IL-25/ILC2 axis promotes lung cancer with a concomitant accumulation of immune-suppressive cells in tumors in humans and mice

BackgroundGroup 2 innate lymphoid cells (ILC2) can be activated by interleukin (IL)-33 or IL-25. IL-25-activated ILC2 cells help protect the host against helminth infection while exacerbating allergic-like inflammation and tissue damage in the lung. In the context of cancer, IL-33-activated ILC2 cel...

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Bibliographic Details
Main Authors: Ilham Bahhar, Zeynep Eş, Oğuzhan Köse, Akif Turna, Mehmet Zeki Günlüoğlu, Aslı Çakır, Deniz Duralı, Fay C. Magnusson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
innate lymphoid cells group 2
non-small cell lung cancer
myeloid-derived suppressor cells
regulatory T lymphocytes
innate immunity
adoptive transfer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1244437/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1244437/full

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