Gambogic acid inhibits tumor metastasis through blocking matrix metalloproteinases mediated TGF-β1 activation

Gambogic acid inhibits tumor metastasis through blocking matrix metalloproteinases mediated TGF-β1 activation

Context: Tumor metastasis is the major death factor in cancer patients. Transforming growth factor-β (TGF-β) is an important cytokine promoting tumor metastasis and blocking TGF-β shows crucial antitumor application prospects. In the tumor microenvironment (TME), TGF-β is always highly activated and...

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Bibliographic Details
Main Authors: Bin Li, Shaoxia Liu, Bin Zhao, Xiaoxian Huang, Ze Zhao, Zhongtao Zhang, Yuting Zhao, Feng Feng, Jingwei Xue, Fulei Liu
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Phytomedicine Plus
Subjects:
Gambogic acid
TGF-β
Matrix metalloproteinase
Tumor metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2667031323000520

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