Three-dimensional and single-cell sequencing of liver cancer reveals comprehensive host-virus interactions in HBV infection

Three-dimensional and single-cell sequencing of liver cancer reveals comprehensive host-virus interactions in HBV infection

BackgroundsHepatitis B virus (HBV) infection is a major risk factor for chronic liver diseases and liver cancer (mainly hepatocellular carcinoma, HCC), while the underlying mechanisms and host-virus interactions are still largely elusive.MethodsWe applied HiC sequencing to HepG2 (HBV-) and HepG2-2.2...

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Bibliographic Details
Main Authors: Mengbiao Guo, Zhicheng Yao, Chen Jiang, Zhou Songyang, Lian Gan, Yuanyan Xiong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
HBV
liver cancer
host-virus interaction
Hi-C
TAD and A/B compartments
structural variation (SV)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161522/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161522/full

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