Multilineage polyclonal engraftment of Cal-1 gene-modified cells and in vivo selection after SHIV infection in a nonhuman primate model of AIDS

Multilineage polyclonal engraftment of Cal-1 gene-modified cells and in vivo selection after SHIV infection in a nonhuman primate model of AIDS

We have focused on gene therapy approaches to induce functional cure/remission of HIV-1 infection. Here, we evaluated the safety and efficacy of the clinical grade anti-HIV lentiviral vector, Cal-1, in pigtailed macaques (Macaca nemestrina). Cal-1 animals exhibit robust levels of gene marking in mye...

Full description

Bibliographic Details
Main Authors: Christopher W. Peterson, Kevin G. Haworth, Bryan P. Burke, Patricia Polacino, Krystin K. Norman, Jennifer E. Adair, Shiu-Lok Hu, Jeffrey S. Bartlett, Geoff P. Symonds, Hans-Peter Kiem
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050116301851

Internet

http://www.sciencedirect.com/science/article/pii/S2329050116301851

Similar Items