Issues with RNF43 antibodies to reliably detect intracellular location

Issues with RNF43 antibodies to reliably detect intracellular location

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RNF43 is an important negative regulator of β-catenin signaling by removing Wnt-receptors from the membrane. It is often mutated in cancers, leading to aberrant Wnt-dependent nuclear translocation of β-catenin. RNF43 has also been suggested to regulate β-catenin signaling directly within the nucleus...

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Bibliographic Details
Main Authors: Shanshan Li, Ruyi Zhang, Marla Lavrijsen, Thierry P. P. van den Bosch, Maikel P. Peppelenbosch, Ron Smits
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079101/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079101/?tool=EBI

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