Docking-Based 3D-QSAR Studies for 1,3,4-oxadiazol-2-one Derivatives as FAAH Inhibitors

Docking-Based 3D-QSAR Studies for 1,3,4-oxadiazol-2-one Derivatives as FAAH Inhibitors

This work aimed to construct 3D-QSAR CoMFA and CoMSIA models for a series of 31 FAAH inhibitors, containing the 1,3,4-oxadiazol-2-one moiety. The obtained models were characterized by good statistical parameters: CoMFA Q<sup>2</sup> = 0.61, R<sup>2</sup> = 0.98; CoMSIA Q<s...

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Bibliographic Details
Main Authors: Agata Zięba, Tuomo Laitinen, Jayendra Z. Patel, Antti Poso, Agnieszka A. Kaczor
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
3D QSAR
CoMFA model
CoMSIA model
FAAH inhibitors
Online Access:https://www.mdpi.com/1422-0067/22/11/6108

Internet

https://www.mdpi.com/1422-0067/22/11/6108

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