Upregulation of interferon-γ response genes in monocytes and T cells identified by single-cell transcriptomics in patients with anti-citrullinated peptide antibody-positive early rheumatoid arthritis

Upregulation of interferon-γ response genes in monocytes and T cells identified by single-cell transcriptomics in patients with anti-citrullinated peptide antibody-positive early rheumatoid arthritis

IntroductionOur aim was to investigate the insufficiently understood differences in the immune system between anti-citrullinated peptide antibody (ACPA)-positive (ACPA+) and ACPA-negative (ACPA-) early rheumatoid arthritis (eRA) patients.MethodsWe performed multiple cytokine assays using sera from d...

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Bibliographic Details
Main Authors: Bong-Ki Hong, Sungyong You, Jung Gon Kim, Minhyung Kim, Naeun Lee, Kijun Lee, In-Pyo Baek, Ji Hyeon Ju, Wan-Uk Kim, Ho-Youn Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
single-cell transcriptomics
peripheral blood mononuclear cells
anti-citrullinated peptide antibody
rheumatoid arthritis
rheumatoid arthritis pathogenesis
Th1 immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1439082/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1439082/full

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