Analysis of Mutational Profile of Hypopharyngeal and Laryngeal Head and Neck Squamous Cell Carcinomas Identifies KMT2C as a Potential Tumor Suppressor

Analysis of Mutational Profile of Hypopharyngeal and Laryngeal Head and Neck Squamous Cell Carcinomas Identifies KMT2C as a Potential Tumor Suppressor

Hypopharyngeal cancer is a poorly characterized type of head and neck squamous cell carcinoma (HNSCC) with bleak prognosis and only few studies focusing specifically on the genomic profile of this type of cancer. We performed molecular profiling of 48 HPV (Human Papilloma Virus)-negative tumor sampl...

Full description

Bibliographic Details
Main Authors: Marcin M. Machnicki, Anna Rzepakowska, Joanna I. Janowska, Monika Pepek, Alicja Krop, Katarzyna Pruszczyk, Piotr Stawinski, Malgorzata Rydzanicz, Jakub Grzybowski, Barbara Gornicka, Maciej Wnuk, Rafal Ploski, Ewa Osuch-Wojcikiewicz, Tomasz Stoklosa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
laryngeal cancer
Kmt2c
MLL3
mutational landscape
head and neck squamous cell carcinoma (HNSCC)
hypopharyngeal cancer (HPC)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.768954/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.768954/full

Similar Items