Antitumor effects of the small molecule DMAMCL in neuroblastoma via suppressing aerobic glycolysis and targeting PFKL

Antitumor effects of the small molecule DMAMCL in neuroblastoma via suppressing aerobic glycolysis and targeting PFKL

Abstract Background Neuroblastoma (NB) is a common solid malignancy in children that is associated with a poor prognosis. Although the novel small molecular compound Dimethylaminomicheliolide (DMAMCL) has been shown to induce cell death in some tumors, little is known about its role in NB. Methods W...

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Bibliographic Details
Main Authors: Simeng Zhang, Zhongyan Hua, Gen Ba, Ning Xu, Jianing Miao, Guifeng Zhao, Wei Gong, Zhihui Liu, Carol J. Thiele, Zhijie Li
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Cancer Cell International
Subjects:
Neuroblastoma
DMAMCL
Apoptosis
Aerobic glycolysis
PFKL
Online Access:https://doi.org/10.1186/s12935-021-02330-y

Internet

https://doi.org/10.1186/s12935-021-02330-y

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