Macrophage-derived exosomes mediate glomerular endothelial cell dysfunction in sepsis-associated acute kidney injury

Macrophage-derived exosomes mediate glomerular endothelial cell dysfunction in sepsis-associated acute kidney injury

Abstract Background Sepsis-associated AKI has been shown to be related to sepsis mortality. Macrophage activation and endothelial cell damage are involved in the progression of sepsis-associated AKI, but the specific mechanisms are still unclear. Methods In vitro experiments, exosomes extracted from...

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Bibliographic Details
Main Authors: Huiling Xiang, Zhifeng Xu, Chun Zhang, Jing Xiong
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cell & Bioscience
Subjects:
Exosome
Macrophage
Sepsis
Acute kidney injury
Acid sphingomyelinase
Online Access:https://doi.org/10.1186/s13578-023-00990-z

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