Tissue-specific transcriptomic changes associated with AmBisome® treatment of BALB/c mice with experimental visceral leishmaniasis [version 1; peer review: 2 approved]

Background: Liposomal amphotericin B (AmBisome®) as a treatment modality for visceral leishmaniasis (VL) has had significant impact on patient care in some but not all regions where VL is endemic.  As the mode of action of AmBisome® in vivo is poorly understood, we compared the tissue-specific trans...

Full description

Bibliographic Details
Main Authors: Sarah Forrester, Karin Siefert, Helen Ashwin, Najmeeyah Brown, Andrea Zelmar, Sally James, Dimitris Lagos, Jon Timmis, Mitali Chatterjee, Jeremy C. Mottram, Simon L. Croft, Paul M. Kaye
Format: Article
Language:English
Published: Wellcome 2019-12-01
Series:Wellcome Open Research
Online Access:https://wellcomeopenresearch.org/articles/4-198/v1