In planta deglycosylation improves the SARS-CoV-2 neutralization activity of recombinant ACE2-Fc

In planta deglycosylation improves the SARS-CoV-2 neutralization activity of recombinant ACE2-Fc

SARS-CoV-2 infects human cells via binding of the viral spike glycoprotein to its main cellular receptor, angiotensin-converting enzyme 2 (ACE2). The spike protein-ACE2 receptor interaction is therefore a major target for the development of therapeutic or prophylactic drugs to combat coronavirus inf...

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Bibliographic Details
Main Authors: Shiva Izadi, Ulrike Vavra, Stanislav Melnik, Clemens Grünwald-Gruber, Esther Föderl-Höbenreich, Markus Sack, Kurt Zatloukal, Josef Glössl, Eva Stöger, Lukas Mach, Alexandra Castilho, Richard Strasser
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
COVID-19
glycosylation
posttranslational modification
recombinant protein expression
glycoengineering
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1180044/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1180044/full

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