Doxorubicin impacts chromatin binding of HMGB1, Histone H1 and retinoic acid receptor

Doxorubicin impacts chromatin binding of HMGB1, Histone H1 and retinoic acid receptor

Abstract Doxorubicin (Dox), a widely used anticancer DNA-binding drug, affects chromatin in multiple ways, and these effects contribute to both its efficacy and its dose-limiting side effects, especially cardiotoxicity. Here, we studied the effects of Dox on the chromatin binding of the architectura...

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Bibliographic Details
Main Authors: Rosevalentine Bosire, Lina Fadel, Gábor Mocsár, Péter Nánási, Pialy Sen, Anshu Kumar Sharma, Muhammad Umair Naseem, Attila Kovács, Jennifer Kugel, Guido Kroemer, György Vámosi, Gábor Szabó
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-11994-z

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https://doi.org/10.1038/s41598-022-11994-z

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