What a Difference an Amino Acid Makes: An All-Atom Simulation Study of Nonameric Peptides in Inhibitory HLA-E/NKG2A/CD94 Immune Complexes

What a Difference an Amino Acid Makes: An All-Atom Simulation Study of Nonameric Peptides in Inhibitory HLA-E/NKG2A/CD94 Immune Complexes

MHC class I antigen E (HLA-E), a ligand for the inhibitory NKG2A/CD94 receptor of the immune system, is responsible for evading the immune surveillance in several settings, including senescent cell accumulation and tumor persistence. The formation of this ligand-receptor interaction promotes the inh...

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Bibliographic Details
Main Authors: Eva Prašnikar, Andrej Perdih, Jure Borišek
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
immune system checkpoint
peptide design
HLA-E
NK cell
T-cell
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.925427/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.925427/full

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