Toll-like receptor 4 deficiency or inhibition does not modulate survival and neurofunctional outcome in a murine model of cardiac arrest and resuscitation.

Toll-like receptor 4 deficiency or inhibition does not modulate survival and neurofunctional outcome in a murine model of cardiac arrest and resuscitation.

<h4>Background</h4>Patients experiencing cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) often die or suffer from severe neurological impairment. Post resuscitation syndrome is characterized by a systemic inflammatory response. Toll-like receptor 4 (TLR4) is a major mediator...

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Bibliographic Details
Main Authors: Stefan Bergt, Andrea Grub, Melanie Mueller, Rika Bajorat, Ivan Barilar, Brigitte Vollmar, Jan Patrick Roesner, Nana-Maria Wagner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0220404

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https://doi.org/10.1371/journal.pone.0220404

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