Pharmacokinetics of Pimobendan and Its Metabolite O-Desmethyl-Pimobendan Following Rectal Administration to Healthy Dogs

Pharmacokinetics of Pimobendan and Its Metabolite O-Desmethyl-Pimobendan Following Rectal Administration to Healthy Dogs

Objective: This study describes the pharmacokinetics of parent pimobendan (PIM) and its active metabolite, o-desmethyl-pimobendan (ODMP), after oral and rectal administration of pimobendan to healthy dogs.Animals: A total of eight healthy privately owned dogs were used in this study.Procedures: The...

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Bibliographic Details
Main Authors: Jiwoong Her, Kendon W. Kuo, Randolph L. Winter, Crisanta Cruz-Espindola, Lenore M. Bacek, Dawn M. Boothe
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Veterinary Science
Subjects:
congestive heart failure
rectal drug administration
pharmacokinetics
pimobendan
bioavailability
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2020.00423/full

Internet

https://www.frontiersin.org/article/10.3389/fvets.2020.00423/full

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