Epistasis, core-genome disharmony, and adaptation in recombining bacteria

Epistasis, core-genome disharmony, and adaptation in recombining bacteria

ABSTRACT Recombination of short DNA fragments via horizontal gene transfer (HGT) can introduce beneficial alleles, create genomic disharmony through negative epistasis, and create adaptive gene combinations through positive epistasis. For non-core (accessory) genes, the negative epistatic cost is li...

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Bibliographic Details
Main Authors: Aidan J. Taylor, Koji Yahara, Ben Pascoe, Seungwon Ko, Leonardos Mageiros, Evangelos Mourkas, Jessica K. Calland, Santeri Puranen, Matthew D. Hitchings, Keith A. Jolley, Carolin M. Kobras, Sion Bayliss, Nicola J. Williams, Arnoud H. M. van Vliet, Julian Parkhill, Martin C. J. Maiden, Jukka Corander, Laurence D. Hurst, Daniel Falush, Paul Keim, Xavier Didelot, David J. Kelly, Samuel K. Sheppard
Format: Article
Language:English
Published: American Society for Microbiology 2024-06-01
Series:mBio
Subjects:
Campylobacter
hybridization
epistasis
introgression
horizontal gene transfer
recombination
Online Access:https://journals.asm.org/doi/10.1128/mbio.00581-24

Internet

https://journals.asm.org/doi/10.1128/mbio.00581-24

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