Melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating ATF4 to activate mTOR signaling pathway in chickens

Melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating ATF4 to activate mTOR signaling pathway in chickens

ABSTRACT: Follicular atresia in chickens reduces the number of follicles that can further develop, leading to decrease egg laying. Endoplasmic reticulum stress (ERS) can initiate a unique pathway inducing the apoptosis of follicular granulosa cells, thus reducing egg laying. Melatonin (MEL) is invol...

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Bibliographic Details
Main Authors: Er-ying Hao, Xue-lu Liu, Xiang-yu Chen, Han Xue, Bo-fei Su, Yi-fan Chen, De-he Wang, Lei Shi, Kang Bai, Fei Hou, Jian-ku Hou, Hui-ling Bao, Hui Chen
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Poultry Science
Subjects:
MEL
ERS
mTOR
granulosa cell
chicken
Online Access:http://www.sciencedirect.com/science/article/pii/S0032579124002359

Internet

http://www.sciencedirect.com/science/article/pii/S0032579124002359

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