Genome-wide association study in a rat model of temperament identifies multiple loci for exploratory locomotion and anxiety-like traits

Genome-wide association study in a rat model of temperament identifies multiple loci for exploratory locomotion and anxiety-like traits

Common genetic factors likely contribute to multiple psychiatric diseases including mood and substance use disorders. Certain stable, heritable traits reflecting temperament, termed externalizing or internalizing, play a large role in modulating vulnerability to these disorders. To model these herit...

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Bibliographic Details
Main Authors: Apurva S. Chitre, Elaine K. Hebda-Bauer, Peter Blandino, Hannah Bimschleger, Khai-Minh Nguyen, Pamela Maras, Fei Li, A. Bilge Ozel, Yanchao Pan, Oksana Polesskaya, Riyan Cheng, Shelly B. Flagel, Stanley J. Watson, Jun Li, Huda Akil, Abraham A. Palmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Genetics
Subjects:
GWAS
genome-wide association study
behavior
rat model
anxiety like behaviors
exploratory locomotion
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.1003074/full

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https://www.frontiersin.org/articles/10.3389/fgene.2022.1003074/full

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