CDK12 regulates co-transcriptional splicing and RNA turnover in human cells

CDK12 regulates co-transcriptional splicing and RNA turnover in human cells

Summary: The cyclin-dependent kinase CDK12 has garnered interest as a cancer therapeutic target as DNA damage response genes are particularly suppressed by loss of CDK12 activity. In this study, we assessed the acute effects of CDK12 inhibition on transcription and RNA processing using nascent RNA B...

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Bibliographic Details
Main Authors: Brian Magnuson, Karan Bedi, Ishwarya Venkata Narayanan, Bartlomiej Bartkowiak, Hailey Blinkiewicz, Michelle T. Paulsen, Arno Greenleaf, Mats Ljungman
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:iScience
Subjects:
Biological sciences
molecular biology
cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222013025

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222013025

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