Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway

Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway

Osteoarthritis (OA) is a low-level inflammatory disease in which synovial macrophage M1 polarization exacerbates the progression of synovitis and OA. Notedly, the ROS (reactive oxygen species) level in macrophages is intimately implicated in macrophage M1 polarization. TRPV4 (transient receptor pote...

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Bibliographic Details
Main Authors: Heng Sun, Ziying Sun, Xingquan Xu, Zhongyang Lv, Jiawei Li, Rui Wu, Yuxiang Fei, Guihua Tan, Zizheng Liu, Yuan Liu, Dongquan Shi
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Antioxidants
Subjects:
osteoarthritis (OA)
TRPV4
M1 macrophage polarization
NLRP3
reactive oxygen species (ROS)
Online Access:https://www.mdpi.com/2076-3921/11/12/2315

Internet

https://www.mdpi.com/2076-3921/11/12/2315

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