Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Chemotherapy causes intestinal mucositis, which includes villous atrophy and altered mucosal barrier function. However, there is an uncertainty regarding how the reduced small-intestinal surface area affects the mucosal permeability of the small marker probe mannitol (MW 188), and how the mucosa res...

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Bibliographic Details
Main Authors: Maria-José Cano-Cebrián, David Dahlgren, Fredrik Kullenberg, Karsten Peters, Tobias Olander, Markus Sjöblom, Hans Lennernäs
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
chemotherapy-induced mucositis
intestinal permeability
villus atrophy
cytostatics
toxicity
mannitol
Online Access:https://www.mdpi.com/1422-0067/23/3/1021

Internet

https://www.mdpi.com/1422-0067/23/3/1021

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