Functional Restoration of Exhausted CD8 T Cells in Chronic HIV-1 Infection by Targeting Mitochondrial Dysfunction

Functional Restoration of Exhausted CD8 T Cells in Chronic HIV-1 Infection by Targeting Mitochondrial Dysfunction

CD8 T cell exhaustion is a hallmark of HIV-1 infection, characterized by phenotypic and functional CD8 T cell abnormalities that persist despite years of effective antiretroviral treatment (ART). More recently, the importance of cellular metabolism in shaping T cell antiviral function has emerged as...

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Bibliographic Details
Main Authors: Aljawharah Alrubayyi, Elia Moreno-Cubero, Dan Hameiri-Bowen, Rebecca Matthews, Sarah Rowland-Jones, Anna Schurich, Dimitra Peppa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
CD8 T cell exhaustion
HIV-1
CMV
immunometabolism
mitochondria
oxidative phosphorylation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.908697/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.908697/full

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