Optimizing CRISPR/Cas9 Editing of Repetitive Single Nucleotide Variants

Optimizing CRISPR/Cas9 Editing of Repetitive Single Nucleotide Variants

CRISPR/Cas9, base editors and prime editors comprise the contemporary genome editing toolbox. Many studies have optimized the use of CRISPR/Cas9, as the original CRISPR genome editing system, in substituting single nucleotides by homology directed repair (HDR), although this remains challenging. Stu...

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Bibliographic Details
Main Authors: Inga Usher, Lorena Ligammari, Sara Ahrabi, Emily Hepburn, Calum Connolly, Gareth L. Bond, Adrienne M. Flanagan, Lucia Cottone
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Genome Editing
Subjects:
CRISPR
CRISPR/Cas9
genome editing
prime editing
homology directed repair (HDR)
cell line
Online Access:https://www.frontiersin.org/articles/10.3389/fgeed.2022.932434/full

Internet

https://www.frontiersin.org/articles/10.3389/fgeed.2022.932434/full

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