ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion

ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion

Ataxia-telangiectasia mutated (ATM) protein kinase regulates the DNA damage response (DDR) and is associated with cancer suppression. Here we report a cancer-promoting role for ATM. ATM depletion in metastatic cancer cells reduced cell migration and invasion. Transcription analyses identified a gene...

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Bibliographic Details
Main Authors: Wei-Ta Chen, Nancy D Ebelt, Travis H Stracker, Blerta Xhemalce, Carla L Van Den Berg, Kyle M Miller
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-06-01
Series:eLife
Subjects:
DNA damage
ATM
IL-8
cell migration
ROS
Online Access:https://elifesciences.org/articles/07270

Internet

https://elifesciences.org/articles/07270

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