ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion
Ataxia-telangiectasia mutated (ATM) protein kinase regulates the DNA damage response (DDR) and is associated with cancer suppression. Here we report a cancer-promoting role for ATM. ATM depletion in metastatic cancer cells reduced cell migration and invasion. Transcription analyses identified a gene...
Main Authors: | Wei-Ta Chen, Nancy D Ebelt, Travis H Stracker, Blerta Xhemalce, Carla L Van Den Berg, Kyle M Miller |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2015-06-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/07270 |
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