Lactic acid modified rare earth-based nanomaterials for enhanced radiation therapy by disturbing the glycolysis
Abstract Deficient deposition of X-rays and strong capacity of repairing damage DNA of cancer cells limit the effect of radiation therapy (RT). Herein, we synthesize CsLu2F7 nanoparticles with lactic acid (LA) ligands (CsLu2F7-LA) to overcome these limitations. The high-Z atoms of Lu and Cs can depo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01694-1 |
| _version_ | 1811219400161755136 |
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| author | Hu Liu Han Wang Dalong Ni Youjia Xu |
| author_facet | Hu Liu Han Wang Dalong Ni Youjia Xu |
| author_sort | Hu Liu |
| collection | DOAJ |
| description | Abstract Deficient deposition of X-rays and strong capacity of repairing damage DNA of cancer cells limit the effect of radiation therapy (RT). Herein, we synthesize CsLu2F7 nanoparticles with lactic acid (LA) ligands (CsLu2F7-LA) to overcome these limitations. The high-Z atoms of Lu and Cs can deposit more X-rays for generating enhanced hydroxyl radicals (·OH). Meanwhile, the LA ligand will guide CsLu2F7-LA to target monocarboxylic acid transporter (MCT) and impede the transportation of free LA, leading to decreased glycolysis and DNA damage repair. Consequently, the curative effect of RT will be enhanced and the strategy of LA accumulation induced radiosensitization is proved by in vivo and in vitro experiments, which will bring prospects for enhanced RT with nanomedicine. |
| first_indexed | 2024-04-12T07:26:25Z |
| format | Article |
| id | doaj.art-b02a77ff3d994c838e6dc207bf32c305 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-12T07:26:25Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-b02a77ff3d994c838e6dc207bf32c3052022-12-22T03:42:12ZengBMCJournal of Nanobiotechnology1477-31552022-11-0120111010.1186/s12951-022-01694-1Lactic acid modified rare earth-based nanomaterials for enhanced radiation therapy by disturbing the glycolysisHu Liu0Han Wang1Dalong Ni2Youjia Xu3Department of Orthopedics, The Second Affiliated Hospital of Soochow UniversityDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Orthopedics, The Second Affiliated Hospital of Soochow UniversityAbstract Deficient deposition of X-rays and strong capacity of repairing damage DNA of cancer cells limit the effect of radiation therapy (RT). Herein, we synthesize CsLu2F7 nanoparticles with lactic acid (LA) ligands (CsLu2F7-LA) to overcome these limitations. The high-Z atoms of Lu and Cs can deposit more X-rays for generating enhanced hydroxyl radicals (·OH). Meanwhile, the LA ligand will guide CsLu2F7-LA to target monocarboxylic acid transporter (MCT) and impede the transportation of free LA, leading to decreased glycolysis and DNA damage repair. Consequently, the curative effect of RT will be enhanced and the strategy of LA accumulation induced radiosensitization is proved by in vivo and in vitro experiments, which will bring prospects for enhanced RT with nanomedicine.https://doi.org/10.1186/s12951-022-01694-1NanomedicineRare earthRadiation therapyLactic acidGlycolysis |
| spellingShingle | Hu Liu Han Wang Dalong Ni Youjia Xu Lactic acid modified rare earth-based nanomaterials for enhanced radiation therapy by disturbing the glycolysis Journal of Nanobiotechnology Nanomedicine Rare earth Radiation therapy Lactic acid Glycolysis |
| title | Lactic acid modified rare earth-based nanomaterials for enhanced radiation therapy by disturbing the glycolysis |
| title_full | Lactic acid modified rare earth-based nanomaterials for enhanced radiation therapy by disturbing the glycolysis |
| title_fullStr | Lactic acid modified rare earth-based nanomaterials for enhanced radiation therapy by disturbing the glycolysis |
| title_full_unstemmed | Lactic acid modified rare earth-based nanomaterials for enhanced radiation therapy by disturbing the glycolysis |
| title_short | Lactic acid modified rare earth-based nanomaterials for enhanced radiation therapy by disturbing the glycolysis |
| title_sort | lactic acid modified rare earth based nanomaterials for enhanced radiation therapy by disturbing the glycolysis |
| topic | Nanomedicine Rare earth Radiation therapy Lactic acid Glycolysis |
| url | https://doi.org/10.1186/s12951-022-01694-1 |
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