Altered intestinal barrier contributes to cognitive impairment in old mice with constipation after sevoflurane anesthesia

Altered intestinal barrier contributes to cognitive impairment in old mice with constipation after sevoflurane anesthesia

BackgroundElderly patients have a high risk of developing postoperative cognitive dysfunction (POCD). Gastrointestinal disorders, such as constipation, in the elderly population may be involved in the pathogenesis of neurological disorders by promoting inflammatory responses due to a ‘leaky gut’. Ge...

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Bibliographic Details
Main Authors: Tianyun Zhao, Junming Lu, Jingwen Qin, Yanxin Chen, Ziwen Shi, Wei Wei, Peng Xiong, Daqing Ma, Xingrong Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Nutrition
Subjects:
perioperative neurocognitive dysfunction
gastrointestinal dysfunction
slow transit constipation
gut permeability
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2023.1117028/full

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https://www.frontiersin.org/articles/10.3389/fnut.2023.1117028/full

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