The interleukin (IL)-1a precursor is biologically active and is likely a key alarmin in the IL-1 family of cytokines

The interleukin (IL)-1a precursor is biologically active and is likely a key alarmin in the IL-1 family of cytokines

Among the eleven members of the IL-1 family cytokines, the precursors of IL-1a, IL-1b, and IL-33 have relatively long N-terminal pro-sequences of approximately one hundred amino acid residues prior to the N-terminus of the mature forms. Compared to the mature forms secreted from the cell, 80-90% of...

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Bibliographic Details
Main Authors: Busun eKim, Youngmin eLee, Eunsom eKim, Areum eKwak, Soyoon eRyoo, Seunghyeon eBae, Tania eAzam, Soohyun eKim, Charles A. Dinarello
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Immunology
Subjects:
DAMPs
recombinant protein
Sterile Inflammation
Precursor IL-1
IL-1 family cytokine
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00391/full

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http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00391/full

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