REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids

REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids

Abstract Cutaneous atrophy is the major adverse effect of topical glucocorticoids; however, its molecular mechanisms are poorly understood. Here, we identify stress‐inducible mTOR inhibitor REDD1 (regulated in development and DNA damage response 1) as a major molecular target of glucocorticoids, whi...

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Bibliographic Details
Main Authors: Gleb Baida, Pankaj Bhalla, Kirill Kirsanov, Ekaterina Lesovaya, Marianna Yakubovskaya, Kit Yuen, Shuchi Guo, Robert M Lavker, Ben Readhead, Joel T Dudley, Irina Budunova
Format: Article
Language:English
Published: Springer Nature 2014-12-01
Series:EMBO Molecular Medicine
Subjects:
glucocorticoid
glucocorticoid receptor
mTOR
REDD1
skin atrophy
Online Access:https://doi.org/10.15252/emmm.201404601

Internet

https://doi.org/10.15252/emmm.201404601

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