Pseudotyping of HIV-1 with Human T-Lymphotropic Virus 1 (HTLV-1) Envelope Glycoprotein during HIV-1–HTLV-1 Coinfection Facilitates Direct HIV-1 Infection of Female Genital Epithelial Cells: Implications for Sexual Transmission of HIV-1

Pseudotyping of HIV-1 with Human T-Lymphotropic Virus 1 (HTLV-1) Envelope Glycoprotein during HIV-1–HTLV-1 Coinfection Facilitates Direct HIV-1 Infection of Female Genital Epithelial Cells: Implications for Sexual Transmission of HIV-1

ABSTRACT Female genital epithelial cells cover the genital tract and provide the first line of protection against infection with sexually transmitted pathogenic viruses. These cells normally are impervious to HIV-1. We report that coinfection of cells by HIV-1 and another sexually transmitted virus,...

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Bibliographic Details
Main Authors: Yuyang Tang, Alvin M. George, Oksana Petrechko, Franklin J. Nouvet, Stephanie D. Sweet, Yuetsu Tanaka, Brian S. Imbiakha, Guochun Jiang, Wei Gao, Kathryn Anastos, James E. K. Hildreth
Format: Article
Language:English
Published: American Society for Microbiology 2018-04-01
Series:mSphere
Subjects:
envelope glycoprotein
epithelial cells
human T-cell leukemia virus
human immunodeficiency virus
primary T-cells
pseudotype
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00038-18

Internet

https://journals.asm.org/doi/10.1128/mSphere.00038-18

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