Targeting Nrf2 with 3 H-1,2-dithiole-3-thione to moderate OXPHOS-driven oxidative stress attenuates IL-17A-induced psoriasis

Targeting Nrf2 with 3 H-1,2-dithiole-3-thione to moderate OXPHOS-driven oxidative stress attenuates IL-17A-induced psoriasis

Psoriasis, a chronic autoimmune disease characterized by the hyperproliferation of keratinocytes in the epidermis and parakeratosis, significantly impacts quality of life. Interleukin (IL)− 17A dominates the pathogenesis of psoriasis and facilitates reactive oxygen species (ROS) accumulation, which...

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Bibliographic Details
Main Authors: Chuan-Teng Liu, Jui-Hung Jimmy Yen, Dennis A Brown, Ying-Chyi Song, Mei-Yun Chu, Yu-Hsiang Hung, Yi-Huan Tang, Po-Yuan Wu, Hung-Rong Yen
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
3 H-1,2-dithiole-3-thione
IL-17A
Nuclear factor erythroid 2–related factor 2 (Nrf2)
Oxidative phosphorylation
Psoriasis
Reactive oxygen species (ROS)
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223000823

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http://www.sciencedirect.com/science/article/pii/S0753332223000823

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