Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model

Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model

Vaccine-mediated cancer treatment is unlikely to induce long-term survival unless suppressive mechanisms are overcome. Given the success of antibody-mediated immune checkpoint blockade in relieving regulation of endogenous anti-tumor T cell responses in tumor-burdened hosts, we investigated whether...

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Bibliographic Details
Main Authors: Cameron S. Field, Martin K. Hunn, Peter M. Ferguson, Christiane Ruedl, Lindsay R. Ancelet, Ian F. Hermans
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:OncoImmunology
Subjects:
vaccine
checkpoint blockade
anti-ctla-4
glioma
tcr sequencing
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1376154

Internet

http://dx.doi.org/10.1080/2162402X.2017.1376154

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