Three-Dimensional Structural Stability and Local Electrostatic Potential at Point Mutations in Spike Protein of SARS-CoV-2 Coronavirus

Three-Dimensional Structural Stability and Local Electrostatic Potential at Point Mutations in Spike Protein of SARS-CoV-2 Coronavirus

The contagiousness of SARS-CoV-2 β-coronavirus is determined by the virus–receptor electrostatic association of its positively charged spike (S) protein with the negatively charged angiotensin converting enzyme-2 (ACE2 receptor) of the epithelial cells. If some mutations occur, the electrostatic pot...

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Bibliographic Details
Main Authors: Svetlana H. Hristova, Alexandar M. Zhivkov
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
SARS-CoV-2
coronavirus variants
point mutations
S-protein
ACE2 receptor
protein electrostatics
Online Access:https://www.mdpi.com/1422-0067/25/4/2174

Internet

https://www.mdpi.com/1422-0067/25/4/2174

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