RETRACTED: An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients

RETRACTED: An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients

Alzheimer's disease (AD) is the most common cause of dementia and is likely caused by defective amyloid precursor protein (APP) trafficking and processing in neurons leading to amyloid plaques containing the amyloid-β (Aβ) APP peptide byproducts. Understanding how APP is targeted to selected de...

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Bibliographic Details
Main Authors: Ebbe T. Poulsen, Filomena Iannuzzi, Helle F. Rasmussen, Thorsten J. Maier, Jan J. Enghild, Arne L. Jørgensen, Carmela Matrone
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
APP
Alzheimer's disease
Tyrosine phosphorylation
Presenilin mutations
Fyn kinase
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2017.00059/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2017.00059/full

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