Straightjacket/α2δ3 deregulation is associated with cardiac conduction defects in myotonic dystrophy type 1

Straightjacket/α2δ3 deregulation is associated with cardiac conduction defects in myotonic dystrophy type 1

Cardiac conduction defects decrease life expectancy in myotonic dystrophy type 1 (DM1), a CTG repeat disorder involving misbalance between two RNA binding factors, MBNL1 and CELF1. However, how DM1 condition translates into conduction disorders remains poorly understood. Here we simulated MBNL1 and...

Full description

Bibliographic Details
Main Authors: Emilie Auxerre-Plantié, Masayuki Nakamori, Yoan Renaud, Aline Huguet, Caroline Choquet, Cristiana Dondi, Lucile Miquerol, Masanori P Takahashi, Geneviève Gourdon, Guillaume Junion, Teresa Jagla, Monika Zmojdzian, Krzysztof Jagla
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
myotonic dystrophy type 1
Drosophila
heart
conduction defects
TU-tagging
Online Access:https://elifesciences.org/articles/51114

Internet

https://elifesciences.org/articles/51114

Similar Items