Cefiderocol Resistance in Klebsiella pneumoniae Is Linked to SHV Extended-Spectrum β-Lactamase Activities and Functional Loss of the Outer Membrane Porin OmpK35

Cefiderocol Resistance in Klebsiella pneumoniae Is Linked to SHV Extended-Spectrum β-Lactamase Activities and Functional Loss of the Outer Membrane Porin OmpK35

ABSTRACT Klebsiella pneumoniae AR 0047 from the CDC and FDA Antibiotic Resistance Isolate Bank is resistant to cefiderocol, a siderophore-conjugated cephalosporin. Genomics analysis and genetic complementation revealed that a frameshift mutation in ompK35 contributed to cefiderocol resistance. Heter...

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Bibliographic Details
Main Authors: Sun Hee Moon, En Huang
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
cefiderocol
resistance
blaSHV
avibactam
Klebsiella pneumoniae
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03496-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.03496-22

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