Shaping Pancreatic β-Cell Differentiation and Functioning: The Influence of Mechanotransduction

Shaping Pancreatic β-Cell Differentiation and Functioning: The Influence of Mechanotransduction

Embryonic and pluripotent stem cells hold great promise in generating β-cells for both replacing medicine and novel therapeutic discoveries in diabetes mellitus. However, their differentiation in vitro is still inefficient, and functional studies reveal that most of these β-like ce...

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Bibliographic Details
Main Authors: Galli Alessandra, Marku Algerta, Marciani Paola, Schulte Carsten, Lenardi Cristina, Milani Paolo, Maffioli Elisa, Tedeschi Gabriella, Perego Carla
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
β-cells
mechanotransduction
diabetes
stem cells
nanotopography
islet of langerhans
integrin
yap/taz
actin
Online Access:https://www.mdpi.com/2073-4409/9/2/413

Internet

https://www.mdpi.com/2073-4409/9/2/413

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