Benzimidazole Derivatives as New and Selective Inhibitors of Arginase from <i>Leishmania mexicana</i> with Biological Activity against Promastigotes and Amastigotes

Benzimidazole Derivatives as New and Selective Inhibitors of Arginase from <i>Leishmania mexicana</i> with Biological Activity against Promastigotes and Amastigotes

Leishmaniasis is a disease caused by parasites of the <i>Leishmania</i> genus that affects 98 countries worldwide, 2 million of new cases occur each year and more than 350 million people are at risk. The use of the actual treatments is limited due to toxicity concerns and the apparition...

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Bibliographic Details
Main Authors: Irene Betancourt-Conde, Claudia Avitia-Domínguez, Alicia Hernández-Campos, Rafael Castillo, Lilián Yépez-Mulia, Jesús Oria-Hernández, Sara T. Méndez, Erick Sierra-Campos, Mónica Valdez-Solana, Siseth Martínez-Caballero, Juan A. Hermoso, Antonio Romo-Mancillas, Alfredo Téllez-Valencia
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
leishmaniasis
arginase
virtual screening
enzyme inhibition
molecular dynamics
benzimidazole derivatives
Online Access:https://www.mdpi.com/1422-0067/22/24/13613

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https://www.mdpi.com/1422-0067/22/24/13613

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