Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function

Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function

In the present study, we aimed to evaluate the effect of Sirt1, Sirt3 and combined activation in high fructose diet-induced insulin resistance rat heart and assessed the cardiac function focusing on mitochondrial health and function. We administered the Sirt1 activator; SRT1720 (5 mg/kg, i.p.), Sirt...

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Bibliographic Details
Main Authors: Bugga Paramesha, Mohammed Soheb Anwar, Himanshu Meghwani, Subir Kumar Maulik, Sudheer Kumar Arava, Sanjay K Banerjee
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Antioxidants
Subjects:
insulin resistance
oxidative stress
mitochondrial dysfunction
OXPHOS
Online Access:https://www.mdpi.com/2076-3921/10/3/338

Internet

https://www.mdpi.com/2076-3921/10/3/338

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