Cumulative mtDNA damage and mutations contribute to the progressive loss of RGCs in a rat model of glaucoma

Cumulative mtDNA damage and mutations contribute to the progressive loss of RGCs in a rat model of glaucoma

Glaucoma is a chronic neurodegenerative disease characterized by the progressive loss of retinal ganglion cells (RGCs). Mitochondrial DNA (mtDNA) alterations have been documented as a key component of many neurodegenerative disorders. However, whether mtDNA alterations contribute to the progressive...

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Bibliographic Details
Main Authors: Ji-hong Wu, Sheng-hai Zhang, John M. Nickerson, Feng-juan Gao, Zhongmou Sun, Xin-ya Chen, Shu-jie Zhang, Rong Zhang, Feng Gao, Jun-yi Chen, Yi Luo, Yan Wang, Xing-huai Sun
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neurobiology of Disease
Subjects:
Retinal ganglion cell
Glaucoma
Mitochondrial DNA
Mutation
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611400360X

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http://www.sciencedirect.com/science/article/pii/S096999611400360X

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