Fasciola hepatica extract suppresses fibroblast-like synoviocytes in vitro and alleviates experimental arthritis

Fasciola hepatica extract suppresses fibroblast-like synoviocytes in vitro and alleviates experimental arthritis

Abstract Background Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation, fibroblast-like synoviocytes (FLS) activation and joint destruction. Fasciola hepatica is a platyhelminth that releases excretory-secretory immunomodulatory products capable of sup...

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Main Authors: Suelen Pizzolatto Dalmolin, Renata Ternus Pedó, Thales Hein da Rosa, Jordana Miranda de Souza Silva, Mirian Farinon, Maria Luísa Gasparini, Eduardo Cremonese Filippi Chiela, Ana Helena Paz, Martín Pablo Cancela Sehabiague, Henrique Bunselmeyer Ferreira, Rafaela Cavalheiro do Espírito Santo, Fabiany da Costa Gonçalves, Ricardo Machado Xavier
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Advances in Rheumatology
Subjects:
Rheumatoid arthritis
Fibroblast-like synoviocytes
Antigen-induced arthritis
Collagen-induced arthritis
Fasciola hepatica
Online Access:https://doi.org/10.1186/s42358-022-00275-y

Internet

https://doi.org/10.1186/s42358-022-00275-y

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