Mettl3 deficiency leads to the upregulation of Cav1.2 and increases arrhythmia susceptibility in mice

Mettl3 deficiency leads to the upregulation of Cav1.2 and increases arrhythmia susceptibility in mice

Methyltransferase-like 3 (Mettl3) is a component of methyltransferase complex that mediates m<sup>6</sup>A modification of RNAs, and participates in multiple biological processes. However, the role of Mettl3 in cardiac electrophysiology remains unknown. This study aims to explore the ven...

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Bibliographic Details
Main Authors: Shi Ling, Jin Xuexin, Li Zheng, Gong Rui, Guo Yang, Ma Jiudong, Zhang Yang, Cai Benzhi, Yang Baofeng, Gong Dongmei, Pan Zhenwei
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-01-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
Mettl3
m<sup>6</sup>A modification
arrhythmia
L-type calcium channel
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2021025

Internet

https://www.sciengine.com/doi/10.3724/abbs.2021025

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