Combination of an autophagy inhibitor with immunoadjuvants and an anti-PD-L1 antibody in multifunctional nanoparticles for enhanced breast cancer immunotherapy

Combination of an autophagy inhibitor with immunoadjuvants and an anti-PD-L1 antibody in multifunctional nanoparticles for enhanced breast cancer immunotherapy

Abstract Background The application of combination therapy for cancer treatment is limited due to poor tumor-specific drug delivery and the abscopal effect. Methods Here, PD-L1- and CD44-responsive multifunctional nanoparticles were developed using a polymer complex of polyethyleneimine and oleic ac...

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Bibliographic Details
Main Authors: Yibin Cheng, Caixia Wang, Huihui Wang, Zhiwei Zhang, Xiaopeng Yang, Yanming Dong, Lixin Ma, Jingwen Luo
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Medicine
Subjects:
Immuno-chemotherapy
Anti-PD-L1 antibody
Multifunctional nanoparticles
Autophagy response
Online Access:https://doi.org/10.1186/s12916-022-02614-8

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