Mutations of 1p genes do not consistently abrogate tumor suppressor functions in 1p-intact neuroblastoma

Mutations of 1p genes do not consistently abrogate tumor suppressor functions in 1p-intact neuroblastoma

Abstract Background Deletion of 1p is associated with poor prognosis in neuroblastoma, however selected 1p-intact patients still experience poor outcomes. Since mutations of 1p genes may mimic the deleterious effects of chromosomal loss, we studied the incidence, spectrum and effects of mutational v...

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Bibliographic Details
Main Authors: Chik Hong Kuick, Jia Ying Tan, Deborah Jasmine, Tohari Sumanty, Alvin Y. J. Ng, Byrrappa Venkatesh, Huiyi Chen, Eva Loh, Sudhanshi Jain, Wan Yi Seow, Eileen H. Q. Ng, Derrick W. Q. Lian, Shui Yen Soh, Kenneth T. E. Chang, Zhi Xiong Chen, Amos H. P. Loh
Format: Article
Language:English
Published: BMC 2022-06-01
Series:BMC Cancer
Subjects:
Neuroblastoma
Chromosome 1
Tumor suppressor
Next-generation sequencing
Synchronous Mutations
Online Access:https://doi.org/10.1186/s12885-022-09800-0

Internet

https://doi.org/10.1186/s12885-022-09800-0

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