Integrated Single Cell and Bulk RNA-Seq Analysis Revealed Immunomodulatory Effects of Ulinastatin in Sepsis: A Multicenter Cohort Study

Integrated Single Cell and Bulk RNA-Seq Analysis Revealed Immunomodulatory Effects of Ulinastatin in Sepsis: A Multicenter Cohort Study

Sepsis is a leading cause of morbidity and mortality in the intensive care unit, which is caused by unregulated inflammatory response leading to organ injuries. Ulinastatin (UTI), an immunomodulatory agent, is widely used in clinical practice and is associated with improved outcomes in sepsis. But i...

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Bibliographic Details
Main Authors: Lin Chen, Senjun Jin, Min Yang, Chunmei Gui, Yingpu Yuan, Guangtao Dong, Weizhong Zeng, Jing Zeng, Guoxin Hu, Lujun Qiao, Jinhua Wang, Yonglin Xi, Jian Sun, Nan Wang, Minmin Wang, Lifeng Xing, Yi Yang, Yan Teng, Junxia Hou, Qiaojie Bi, Huabo Cai, Gensheng Zhang, Yucai Hong, Zhongheng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
sepsis
single cell
ulinastatin
RNA-seq
immunosuppression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.882774/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.882774/full

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